Resources: Videos

NGS QC

QC Solutions for Clinical Next-Generation Sequencing

Welcome to our video series on how to use SeraCare's QC Solutions to get up and running faster and stay up and running longer with your clinical NGS assays. This video series will highlight how you can use SeraCare's QC management solutions to address assay validation, training, troubleshooting, QC review, and QC reporting.

Cancer

Plasma Mutation Spectrum Matches Known Tumor Mutations in Active Cancer Patients

UNC evaluated a test system that preferentially amplifies fragmented DNA to reduce impact of ex vivo release of cellular DNA, and that capitalizes on “unique molecular identifiers” and variable amplicon lengths to improve assay performance.

ctDNA

Multi-Laboratory Assessment of a New Reference Material for Quality Assurance of Circulating Tumor DNA Measurements

The accurate diagnosis and monitoring of cancer, using circulating tumor DNA, is a major challenge, given the low concentration and complexity of the target molecules.

Case Study

An Efficient and Ultrasensitive Next-Generation Sequencing Solution for Profiling Circulating Tumor DNA

Asuragen’s Associate Director of Bioinformatics explains how SeraCare’s ctDNA allows confident quantification of trace levels of ctDNA in their NGS-based assay.

NGS Validation

Reliable Interpretation of NGS Data Using Well-Established, Highly-Multiplexed Reference Material

This video shows how Directed Genomics and New England Biolabs use highly multiplexed reference materials during optimization and validation to fine-tune assay performance.

Validation

A Practical Guide to Clinical Genomics Assay Validation

Dr. Bob Daber, founder of Gnosity Consults, and Dr. Russell Garlick, CSO of SeraCare discuss real-world examples that illustrate how highly multiplexed, patient-like biosynthetic reference materials offer substantial time and cost advantages over traditional materials and methods.

Case Study

Enabling Clinical Genomics with Highly Multiplexed and Patient-Like Reference Materials

Industry expert Dr. Sandi Deans, Consultant Clinical Scientist and Director of UK National External Quality Assessment Service (UK NEQAS) for Molecular Genetics presents a case study of how a global external quality assessment (EQA) organization uses expert-designed, patient-like reference materials to ensure the accuracy and consistency of a clinical genomics application.

Validation

Validate Your Clinical Genomics Assay Without Crushing Your Budget or Sanity

In this video, Drs. Greg Tsongalis and Russell Garlick will review how to employ modern NGS QC tools to accelerate the development of your clinical genomics assay for less than it costs with traditional materials and methods.

NGS Implementation

Roundtable Discussion: Best Practices for Validation, Monitoring, and Controls

Expert panelists provide an overview of the current regulatory landscape for laboratory-developed tests. Our panelists discuss how clinical genomics labs can and should ensure the analytical and clinical validity of their tests amid an uncertain regulatory climate.

Case Study