SARS-CoV-2 Variant Solutions

CLINICAL DIAGNOSTIC QUALITY SOLUTIONS FOR SARS-COV-2 VARIANT ANALYSIS

AccuPlex™ SARS-CoV-2 Variant Panel 1 contains the full SARS-CoV-2 genomic RNA with a focus on S-gene mutations in three prominent variants of concern (VOC):  UK variant B.1.1.7, South Africa variant B.1.351, and Brazil variant P.1. The kit has one vial for each variant as well as a fourth wild type (reference sequence NC_045512) control vial. An RNase P negative control vial is also included.

Product Description Material Number Strain Pack Size Concentration


AccuPlex SARS-CoV-2 Variant Panel 1


0505-0241
UK B.1.1.7
S. Africa B.1.351
Brazil P.1
Wuhan Wild Type
RNase P negative

Positive    4 x 1.5 mL
Negative   1 x 1.5 mL

Positive 15,000 cp/mL
Negative 5,000 cp/mL
Not for In Vitro Diagnostic Use. Research Use Only.

SARS-CoV-2 Variant Solution:

  • Performance confirmation of existing SARS-CoV-2 molecular assays with different variants
  • Reference materials for SARS-CoV-2 variant genotyping assays
  • Reference materials for SARS-CoV-2 NGS assays

Table 1: Mutations and variant strains contained in the AccuPlex SARS-CoV-2 Variant Panel 1

Amino Acid Change

Nucleotide Change

B.1.1.7 UK variant

B.1.351 S. Africa variant

P.1 Japan/Brazil variant

L18F

C21614T

 

 

X

T20N

C21621A

 

 

X

P26S

C21638T

 

 

X

HV 69-70 deletion

21765-21770 deletion

X

 

 

D80A

A21801C

 

X

 

D138Y

G21974T

 

 

X

Y144 deletion

21991-21993 deletion

X

 

 

R190S

G22132T

 

 

X

D215G

A22206G

 

X

 

242_244 DelLAL

22286-22294 Del

 

X

 

K417N

G22813T

 

X

 

K417T

A22812C

 

 

X

E484K

G23012A

 

X

X

N501Y

A23063T

X

X

X

A570D

C23271A

X

 

 

D614G

A23403G

X

X

X

H655Y

C23525T

 

 

X

P681H

C23604A

X

 

 

A701V

C23664T

 

X

 

T716I

C23709T

X

 

 

S982A

T24506G

X

 

 

T1027I

C24642T

 

 

X

D1118H

G24914C

X

 

 

V1176F

G25088T

 

 

X