Seraseq® Inherited Cardiovascular DNA Mix

The Seraseq® Inherited Cardiovascular DNA Mix is a meticulously designed synthetic DNA reference material, engineered to empower laboratories in the development, validation, and routine monitoring of next-generation sequencing (NGS) and other molecular assays targeting inherited cardiovascular diseases.  

This comprehensive mix encompasses 61 clinically-relevant mutations across 56 genes, representing all major cardiomyopathy types, including hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies, as well as arrhythmias and other related syndromes. 

FEATURES AND BENEFITS 

• Comprehensive Variant Coverage for Inherited Cardiovascular Diseases: contains 61 carefully selected mutations in 56 genes, ensuring broad representation of clinically significant variants linked to all major inherited cardiovascular diseases. 

• Expertly Designed: crafted to mimic challenging genomic regions such as microsatellite instability, large deletions in repetitive regions, and large duplications; providing a robust tool for clinical laboratories working on inherited cardiovascular conditions.  

• Clinically Relevant Mutations: all 61 variants are classified as pathogenic or likely pathogenic, adhering to ACMG recommendations, the FDA-recognized database, and/or an expert-reviewed panel.  

• Single-Vial Convenience: Simplify workflows with a highly multiplexed reference material packaged in a single vial, reducing costs and saving time while boosting QC consistency. 

• High-Quality Synthetic DNA: manufactured in cGMP compliant and ISO 13485-certified facilities with precision to ensure accurate and reproducible results, providing confidence in your assay performance. Variants quantified using sensitive dPCR assays and blended with the well-characterized GM24385 genomic background. Orthogonally validated by a targeted NGS panel.