Highly Stable and Commutable NIPT Reference Materials
for Validation, Proficiency Testing and Quality Control
Plasma-based DNA next-generation sequencing (NGS) diagnostics for non-invasive prenatal testing (NIPT) has exploded in popularity in recent years. However, sufficient volumes of patient-derived reference materials for assay validations, proficiency testing, and daily quality checks remain difficult if not impossible to obtain.
Because fragmented DNA degrades in blood or blood-like matrices, stabilization of the fragmented DNA is essential. SeraCare developed a technology and formulation that stabilizes biomimetic NIPT reference materials derived from fragmented genomic DNA (gDNA) for an extended period of time.
Download this poster to see how SeraCare has developed a commutable technology to stabilize small DNA fragments spiked into a synthetic plasma to generate NIPT reference materials that can be used for validations, proficiency testing, and as daily run controls.
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