Seraseq™ Solid Tumor Mutation Mix-I (AF1-10)
Seraseq Solid Tumor Mutation Mix-I (AF1-10) features a set of 26 unique variants across a range of allele frequencies to confirm the lower limits of detection of somatic mutation profiling assays. Seraseq Solid Tumor Mutation Mix-I (AF1-10), eliminates the need to obtain, characterize, blend and document mixes of cell lineages. It is manufactured in cGMP compliant, ISO 9001 and ISO 13485 certified facilities and offers the following key features:
- 26 unique variants including SNVs, SNVs as part of homopolymer tracts, deletions and insertions
- Synthetic variants quantitated with digital PCR
- Five discrete allele-frequency ratios: 1%, 3%, 5%, 8% and 10% in one kit with GM24385 human genomic DNA as background material
Seraseq Solid Tumor Mutation Mix-1 (AF1-10) - List of Mutations
The presence of the mutation in a particular assay depends upon the enrichment strategy and sequencing platform used.
The Seraseq™ Solid Tumor Mutation Mix-I (AF1-10) is formulated for use with targeted next-generation sequencing assays that detect mutations in key oncogenes and tumor suppressor genes. The Seraseq™ Solid Tumor Mutation Mix-I (AF1-10) is intended as a quality material for translational and disease research testing and monitors library preparation, sequencing, and variant allele detection under a given set of bioinformatics pipeline parameters.