As diagnostic testing for chromosomal translocations and other complex structural variants continues to shift from single-site methods such as Fluorescent In Situ Hybridization (FISH) and targeted reverse transcription PCR (RT-PCR) to highly multiplexed next-generation sequencing (NGS) assays, there is an increasing need for highly multiplexed reference materials covering such mutations which may be rare or difficult to obtain. SeraCare continues to innovate to address this critical market need with an updated version designed for use with NGS assays that detect gene fusions via sequencing of RNA transcripts.
Single sample with 16 clinically-relevant RNA fusions (save $1000s in running costs)
Purified RNA format is easy to use and eliminates extraction variability
Quantification of transcript levels by digital PCR establishes ground-truth and simplifies dilutions for limit of detection (LOD) experiments
Total RNA from well-characterized GM24385 cell line as background wild-type material
Manufactured in GMP-compliant and ISO 13485-certified facilities