Seraseq® CNV Copy Loss DNA Mix

Gene amplifications and deletions, collectively called copy number variations (CNVs), are common in cancer cells and contribute to uncontrolled cell growth, drug sensitivity and resistance. To support clinical labs performing NGS-based tumor profiling of cancer patient samples and help assay developers generate and characterize the performance of their assays, LGC/SeraCare has developed a CNV reference material from a cell line containing gene copy losses in purified DNA format. This material carries full or partial copy number loss in the clinically relevant PTEN and TP53 tumor suppressor genes, as well as in the gene encoding methyl thioadenosine phosphorylase (MTAP), which has generated recent attention due to its role in enhancing therapeutic efficacy of drugs in the PRMT5 and MAT2A inhibitor class.

FEATURES AND BENEFITS

• 7 clinically relevant CNV gene copy losses associated with tumors

• A single reference material carrying partial or complete gene copy losses

• Copy numbers quantified using sensitive dPCR assays and/or whole genome, long read sequencing in a cell line background

• Manufactured in GMP-compliant, ISO 13485-certified facilities