White Papers and Brochures

White Papers

Learn more about best practices for the clinical genomics and diagnostics industries, find data and methods to help guide your decisions.

Next-Generation Sequencing Assay Validation: A Practical Guide for the Clinical Genomics Laboratory

This eBook focuses on the validation process for NGS-based assays and will walk through key considerations and guidelines you can follow to ensure a smooth and successful validation.

By reading this eBook, you will learn three key phases of bringing a clinical NGS assay into routine operation:

  • Development (technology selection and optimization)
  • Validation
  • Ongoing assay QC protocols

2 Tools For Overcoming Your Clinical Lab's Toughest Quality Control Challenges

By reading this white paper, you will learn:

  • Why quality control is so challenging for NGS labs
  • How reference materials may be the key to quality control
  • The 9 key characteristics of sufficient NGS reference materials
  • How to use QC metrics to monitor the health of your NGS assays
  • 7 QC data management must-haves

How SeraCare's Reference Material Ensures Diagnostic Results You Can Count On
Finally, Reliable QC for NGS Labs

In this new white paper from SeraCare, you'll learn:

  • About the three QC approaches that lab directors typically use
  • About the pros and cons of each approach
  • About the value of multiplexed, patient-like, ground truth reference materials
  • About the benefits of using SeraCare reference materials and QC tracking software as part of your quality control program


Catalyzing Implementation of NGS-Based Tests: A Four-Part Series Including Clinical Genomics Best Practices & Case Studies

Download now to learn more: Four-Part Series Including Best Practices and Case Studies

  • Improved performance and global standardization in the implementation of assays
  • Real-world examples of how some lab directors are bringing validated tests to the clinic
  • How clinical genomics labs can and should ensure the analytical and clinical validity of their tests




Seraseq™ ctDNA: A Breakthrough QC Technology: The Most Patient-Like ctDNA Reference Material 

The advances in liquid biopsy technology have outpaced improvements of accompanying ctDNA QC materials and methods. The lack of a sustainable source of patient-like reference materials with rare, pathogenic variants has frustrated both assay developers and clinical laboratory directors. We have developed the Seraseq Circulating Tumor DNA Reference Material and Mutation Mix v2 to overcome the inherent challenges of using remnant patient samples and ultrasonicated cancer cell lines for ctDNA assay development and validation.

Download Now


AccuPlexTM Technology for Rapid Development of Molecular Diagnostic Assays in Response to Viral Infectious Diseases Technology for Rapid Development of Molecular Diagnostics

Download this whitepaper to learn:

  • Why AccuPlex reference materials can serve as full‑process controls, positive controls, and internal controls

  • How AccuPlex reference materials were deployed to fight the 2014 Ebola crisis and today's Zika outbreak

  • What enables Accuplex recombinant virus to accommodate large target sequence for highly multiplexed assays while remaining safe to handle

Achieving High Levels of Accuracy from Next-Generation Sequencing Assays in Clinical Laboratories

Download this whitepaper to learn: 

  • How the use of reference materials is critical for validation during clinical NGS test development 

  • The benefits of inter-lab and cross-platform validation

  •  How to optimize NGS assays for clinical diagnostics



Automate the QC Data Analysis of Your Clinical NGS Test

Download this white paper to learn more:

  • Visualize trends and troubleshoot runs at a glance
  • NGS Sequencing Analysis
  • Post-validation daily run QC challenges

Case Studies


QC Solutions Overview

Remove doubt. Add confidence. 
The Most Comprehensive Clinical Genomics Program

SeraCare Cancer Solutions Overview

Cancer Sequencing Tools for NGS-Based Tumor Profiling Assays 

SeraCare Inherited Disease Solutions Overview
Reference Materials for NGS-Based Inherited Disease Assays

SeraCare Clinical Genomics Overview 
QC Tools for Every Phase of Your NGS-Based Genomic Profiling Assay

VariantFlex™ Custom Platform
Easily Build Custom Reference Materials to Fit Your Assay and Budget Within Weeks