SeraCare is one of the world's best known and experienced providers of animal derived proteins for in vitro diagnostics and research. SeraCare offers a variety of grades of Fraction V BSA with a high level of consistency, traceability and quality in small and large volumes.

SeraCare's commitment to quality is evidenced by our excellence in Good Manufacturing Practices (GMP) which ensures that our BSA products meet the exacting standards demanded by diagnostic, biopharmaceutical and research customers worldwide.

Features and Benefits of SeraCare's Bovine Serum Albumin

• High purity, low interference, low background
• Complete origin traceability to facilitate regulatory approval
• Excellent solubility/filterability for ease of use
• Responsive customer/technical services
• Manufactured from USDA-certified Bovine Plasma (New Zealand/Australia also available)
• Validated for Clearance of TSE agents
• Protease-free, IgG-free and virtually free of contaminants that can result in background interference

Product Information

SeraCare bovine serum albumin is a high purity Fraction V protein derived from the plasma of US-origin, USDA-inspected healthy animals. The material is initially fractionated by a modified Cohn procedure and is further isolated from other plasma proteins and lipids by extensive membrane dialysis and filtration. Typical purity levels are in excess of 99%.

Diagnostic Applications

SeraCare offers grades of albumin that are ideally suited for sensitive immunodiagnostic and protein chemistry applications, as well as for automated clinical analysis. All lots are protease-free, IgG-free and virtually free of contaminating enzymes, salts, heavy metals and low molecular-weight contaminants that can result in background interference. Solubility is outstanding, with excellent clarity, filterability and low UV background even at high concentrations. Typical diagnostic applications for SeraCare BSA include:

• Blocking agent for immunoassays, preventing non-specific binding
• Protein standard, diluent, control
• Protein/conjugate/antibody stabilization
• Surface coating agent
• Detoxification and inactivation of inhibitory analytes
• PCR optimization/stabilization
• Immunohematology and serology

Cell Culture, Medical Device Applications

SeraCare's BSA products are very low in endotoxin are low bioburden, have undetectable amounts of IgG and are highly soluble in media - critical characteristics for veterinary and biopharmaceutical cell culture applications. In addition, traceability and document trails facilitate regulatory compliance. Worldwide SeraCare BSA is used successfully as a manufacturing component of vaccines, therapeutics and diagnostics. In addition, our research and development team will assist customers in optimizing products cell lines and our other serum-free media components, such as transferrin and LiProTM lipoprotein supplement.

Typical applications include:

• Serum-free and serum-reduced mammalian cell culture/cell preservation
• Cultivation of Leptospira, Borrelia and mycoplasma; virus production
• Component of topical and ex-vivo medical device formulations

Fatty-Acid Free

SeraCare's albumin is also available as an essentially lipid and fatty-acid free preparation, with levels of non-esterified fatty acids typically < 0.01% (< 0.1mg/g) . SeraCare fatty-acid free BSA is used when the presence of lipids and fatty-acids may cause problems, such as hormone and cholesterol assays. Fatty-acid free albumin also provides maximum binding sites for the addition of specific fatty acids for cell culture applications.

Bovine Albumin Solutions

All SeraCare BSA products are also available as 22% or 30% solutions. Solutions can be provided in a variety of custom configurations.

Regulatory Information

SeraCare's BSA is produced in adherence to FDA Bulk Pharmaceutical Chemicals GMPs. All SOPs and batch records demonstrating compliance with BPC GMPs are on file at the manufacturing site and are available for inspection.