Clinical Specimens

The Global Repository®

All specimens were collected under strict adherence to relevant HIPAA, IRB and informed consent procedures, and material includes:

  • Disease-state Products and Tissues
  • Blood-based specimens
  • DNA and RNA
  • Frozen tissue
  • Isolated Peripheral Blood Mononuclear Cells
  • Paraffin-embedded, formalin-fixed blocks

Patient Conditions Represented by Specimens in the Global Repository - BLOOD-BASED.

Patient Conditions Represented by Specimens in the Global RepositoryŽ: TISSUE

Custom Prospective Collections

The SeraCare network of disciplined sites delivers reliable and efficient custom collections from concept through study design to ultimate delivery of clinical specimens and data. We pay careful attention to ethical guidelines, HIPAA, and informed consent, and our experienced MD, PhD and nursing staff will provide guidance to achieve your objectives in the most efficient manner. Successful results require even more, which we provide:

  • High-value multigenic disease states; client-directed disease-based collections
  • CRF design and management
  • Sample integrity and quality-control
  • Objective inclusion criteria and independent pathologist confirmation of diagnosis
  • Custom specimen collection kits
Collections of : Whole Blood, Serum, Plasma, Tissue, DNA & RNA



Adverse Drug Reaction Cases in the Global Repository®

We have isolated DNA from specific individuals who demonstrated ADRs, based on information from each CRF, for use in toxicgenomic analysis. There is no certainty that they are drug-specific ADRs; however, the ADRs are known to be associated with the indicated drugs, which were taken by the individuals prior to, or concurrent with the apparent ADR.

Elevated Liver Enzymes

  • 7+ individuals receiving a statin drug
  • Multiple individuals receiving Troglitazone and Rofecoxib
  • 20+ indiviidual cases and suspect drugs

Edema

  • 150+ individuals receiving sulfonamides
  • 30+ individuals receiving Rofecoxib, 10+ receiving Celecoxib
  • Multiple individuals receiving Statins, Glitazones, Vaccines, Antimicrobials, NSAIDs and Steroids

Our specimen population changes constantly, as we add some and others are depleted. We also have limited numbers of specimens from other types of ADR cases (e.g., skin rash).



The RTS Thurnall Automated DNA Storage and Retrieval System can pick and return over 2000 DNA samples in an 8 hour shift.

Unique HIV Specimens

SeraCare has assembled a library from unique populations of HIV patients:

  • HIV Candidate Evaluation Panel consists of well-characterized, viable virus isolated from 20 different individuals, and encompasses all major subtypes used to infect cells for in-vitro assessment of anti-HIV activity of candidate compounds.
  • Blood specimens from 60+ HIV-positive individuals receiving atazanvir, idinavir, lopinavir, or nelfinavir, accompanied by CRF information for each.
  • Isolates of drug-resistant HIV mutations and non-infective HIV.